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Airway response to serotonin in PDE4D+/+ and PDE4D−/− mice. Mice were immunized with OVA following the protocol described in Fig. 2. One day after the last i.n. challenge with OVA, AHR in response to increasing concentrations of serotonin was measured in conscious mice. Data are expressed as percentage above baseline (mean ± SEM; n = 8).
