FIG. 4.

Course of parasitemia in immunized B-cell-deficient μ-MT (BKO) and wild-type (WT) C57BL/10 mice. Groups of BKO (male, n = 6; female, n = 8) and WT (male and female, n = 10) mice were immunized s.c. with antigen plus IL-12 in alum and boosted i.p. with antigen 3 weeks later. Two weeks later, mice were challenged i.p. with 10⁶ P. chabaudi AS PRBC and the course of parasitemia was determined in male (A and B) and female (C and D) BKO (A and C) and wild-type (B and D) mice. *, P < 0.001; #, P < 0.05 for nonimmunized versus immunized mice.