TABLE 2.
Long-term protection against blood-stage malaria induced by immunization with malaria antigen plus IL-12 in alum
| Treatment groupa (n) | % Peak parasitemia (mean ± SEM) | Clearance by day: | % Survival |
|---|---|---|---|
| Untreated (10) | 41.25 ± 1.29 | 0 | |
| 2 wk postboost (5) | 15.80 ± 2.29b | 14 | 100 |
| 12 wk postboost (5) | 28.65 ± 1.29c | 15 | 100 |
a
Groups of A/J mice (n = 5) were immunized s.c. with antigen plus 1.0 μg of IL-12 admixed in alum and boosted 3 weeks later by i.p. injection with antigen. For each immunization group, age-matched untreated and immunized mice were infected i.p. with 106 PRBC at 2 or 12 weeks postboost. Since there were no significance differences in peak parasitemia or survival between the two untreated groups (n = 10), data have been pooled.
b
P < 0.001 compared to control.
c
P < 0.001 compared to control.