FIG. 7.
C. albicans Δcmp1 mutants are avirulent. (A) Survival curves of mice intravenously infected with 5 × 105 cells of the Δcmp1 mutant strains CMP1M5A and -B or the respective complemented strains, CMP1MK1A and -B. (B) Macrographs of kidneys from animals infected with strains CMP1MK1B (Δcmp1 + CMP1) (left) or CMP1M5B (Δcmp1) (right). The duration of infection is indicated for each frame (d, day p.i.). (C) Fungal organ burden for kidneys. Shown are average numbers of CFU (+ standard deviations) after infection with 5 × 105 cells of either the Δcmp1 mutant strain CMP1M5B (open bars) or the complemented strain CMP1MK1B (solid bars) calculated for two or three pairs of kidneys. n.d., not detectable.