TABLE 2.
Comparison of the virulence of strains of the B. cepacia complex in a chronic respiratory infection model
| Strain | Virulence (CFU/ml/lung)a
|
% Pathology on day 7 p.i.a | |
|---|---|---|---|
| Day 7 p.i. | Day 21 p.i. | ||
| B. cepacia genomovar I | |||
| Cep509 | 8.1 × 105 ± 6.4 × 105 | 1.2 × 105 ± 1.4 × 105b | 43.0 ± 2.0 |
| B. multivorans | |||
| C5393 | 1.3 × 106 ± 1.4 × 106 | 3.7 × 105 ± 1.5 × 105 | 13.3 ± 5.9 |
| C1576 | 1.2 × 105 ± 1.7 × 105 | 4.5 × 104 ± 4.6 × 104 | 9.0 ± 4.6 |
| B. cepacia genomovar III | |||
| K56-2 | 1.5 × 106 ± 2.4 × 106e | ND | 40.5 ± 4.2e |
| PC715j | 3.5 × 105 ± 3.4 × 105f | ND | 22.8 ± 10.8f |
| J2315 | 4.6 × 103 ± 7.8 × 103 | 5.0 × 102c | 38.0 ± 21.0 |
| Cep511 | 2.7 × 105 ± 2.2 × 105 | 3.3 × 103 ± 5.1 × 103 | 12.7 ± 1.53 |
| J415 | 3.1 × 105 ± 5.2 × 105 | 6.5 × 103 ± 1.2 × 104 | 13.0 ± 1.73 |
| B. stabilis | |||
| LMG 14086 | 3.3 × 102 ± 2.9 × 102 | 0 | 20.0 ± 1.7 |
| LMG 14294 | 0 | 0 | 16.0 ± 5.6 |
| B. vietnamiensis | |||
| PC259 | 1.2 × 104 ± 2.0 × 104 | 2.0 × 102 ± 1.7 × 102 | 19.7 ± 0.6 |
| FC441 | 8.5 × 102 ± 6.6 × 102 | 7.1 × 103 ± 9.3 × 103d | 29.0 ± 1.0 |
Values are means ± standard deviations for three animals unless noted otherwise. ND, not determine
Values are mean ± standard deviation for four animals.
Values are for one animal (one animal died on day 1 p.i., and one animal died on day 2 p.i.).
Values are mean ± standard deviation for five animals.
Data previously reported by Sokol et al. (32).
Values are means ± standard deviations for eight animals in the experiment previously described by Sokol et al. (32).