TABLE 1.
Frequencies of MBL genotypes in Ghanaians with and without malaria due to P. falciparuma
| Genotype or parameter | No. (%) of persons
|
|||||
|---|---|---|---|---|---|---|
| Hospital-based study
|
Community-based study
|
Total | ||||
| Cerebral malaria | Severe malarial anemia | Uncomplicated malaria | P. falciparum positive | P. falciparum negative | ||
| A/A | 67 (47.5) | 30 (41.1) | 56 (51.3) | 65 (44.2) | 39 (48.1) | 257 (46.6) |
| A/B | 1 (0.7) | 1 (1.4) | 0 | 0 | 1 (1.2) | 3 (0.5) |
| A/C | 58 (41.1) | 33 (45.2) | 44 (40.4) | 66 (44.9) | 33 (40.8) | 234 (42.5) |
| Sum A/O | 59 (41.8) | 34 (46.6) | 44 (40.4) | 66 (44.9) | 34 (42.0) | 237 (43.0) |
| B/C | 1 (0.7) | 0 | 0 | 0 | 0 | 1 (0.2) |
| C/C | 14 (9.9) | 9 (12.3) | 9 (8.3) | 16 (10.8) | 8 (9.9) | 56 (10.2) |
| Sum O/O | 15 (10.6) | 9 (12.3) | 9 (8.3) | 16 (10.8) | 8 (9.9) | 57 (10.4) |
| Total | 141 (100) | 73 (100) | 109 (100) | 147 (100) | 81 (100) | 551 (100) |
| Frequency of O allele | 0.32 | 0.36 | 0.28 | 0.33 | 0.31 | 0.32 |
a
A is the common designation for the normal structural allele, while O indicates variant alleles. None of the groups deviated from the Hardy-Weinberg expectations (P > 0.5). No statistically significant difference in gene frequencies was observed between the groups (P > 0.05).