TABLE 2.
Frequencies of low-MBL-producing promoter genotype X (−221) in Ghanaians with and without malaria due to P. falciparuma
| Genotype or parameter | No. (%) of persons
|
|||||
|---|---|---|---|---|---|---|
| Hospital-based study
|
Community-based study
|
Total | ||||
| Cerebral malaria | Severe malaria anemia | Uncomplicated malaria | P. falciparum positive | P. falciparum negative | ||
| YA/YA | 44 (31.2) | 24 (32.9) | 31 (28.4) | 45 (30.6) | 27 (33.3) | 171 (31.0) |
| YA/XA | 22 (15.6) | 5 (6.5) | 24 (22.0) | 19 (12.9) | 19 (13.6) | 81 (14.7) |
| X/A/XA | 2 (1.4) | 1 (1.4) | 1 (0.9) | 1 (0.7) | 1 (1.2) | 6 (1.1) |
| YA/O | 50 (35.5) | 25 (34.3) | 35 (32.1) | 52 (35.4) | 27 (33.3) | 189 (34.3) |
| XA/O | 8 (5.6) | 9 (12.3) | 9 (8.3) | 14 (9.5) | 7 (8.6) | 47 (8.6) |
| O/O | 15 (10.6) | 9 (12.3) | 9 (8.3) | 16 (10.8) | 8 (9.9) | 57 (10.4) |
| Frequency of X allele | 0.12 | 0.11 | 0.16 | 0.12 | 0.12 | 0.13 |
| Sufficient (A/A + YA/O) | 118 (83.7) | 55 (75.3) | 91 (83.5) | 117 (79.6) | 66 (81.5) | 447 (81.1) |
| Insufficient (XA/O + O/O) | 23 (16.3) | 18 (24.7) | 18 (16.5) | 30 (20.4) | 5 (18.5) | 104 (18.9) |
a
A is the common designation for the normal structural allele, while O indicates variant alleles. Y/X indicates a base substitution at position −221 (G to C). The X allele is associated with low MBL concentrations in serum. None of the groups deviated from the Hardy-Weinberg expectations (P > 0.5). No statistically significant difference in gene frequencies was observed between the groups (P > 0.05).