FIG. 3.
Live vaccination with CpG ODNs promotes early containment of parasite growth in the site. Mice were vaccinated in the ear dermis with 104 metacyclic promastigotes alone (▪) or in combination with 50 μg of CpG ODNs (•). (A) Lesion size, expressed as mean induration ± SD for 3 to 10 mice (6 to 20 ears) per group. (B) Parasite number per ear, expressed as geometric mean ± SD (six ears per group). Asterisks indicate statistically significant difference compared with results for mice vaccinated with parasites alone (P < 0.001).