FIG. 8.
Virulence of serotype A strains. (A) Groups of 10 A/Jcr mice were infected with 105 cells of the αA strains H99 and 8-1, the aA strain KNA14, and the fifth-backcross progeny KN99-5a (aA), and survival was monitored. (B) Groups of 10 A/Jcr mice were infected with 5 × 104 cells of H99 (αA) and KN99-5a (aA), and survival was monitored. (C) Groups of three immunosuppressed rabbits were inoculated with 108 cells of strains KN99a (aA), KN99α (αA), and JEC21 (αD). CSF was withdrawn on days 4 and 7 postinfection, and the number of surviving yeast cells was determined by plating serially diluted CSF on YPD medium. (D) Groups of 10 A/Jcr mice were infected with either 105 or 103 cells of strains H99 (αA), KN99a (aA), and KN99α (αA), and survival was monitored. Error bars indicate standard errors of the means.