Table 3.

Results of multiple regression analysis of the relationships between urinary pH and volume and renal clearances of unbound clozapine and metabolites divided by the creatinine clearance.

Estimates of parameters and significances were calculated by the formula ln (CL_Ru/CL_CR)=μ+a_i+b·ln (urine pH) + c · ln(urine volume) with a_i as the patient-dependent intercept. r² is the fraction of total variance explained by the model when individual a values are taken into account.