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Lineweaver-Burk plots for the inhibition of phenacetin O-deethylation activities by mexiletine (○ 0 μm, ▪ 10 μm, ▴ 25 μm, • 50 μm) (a) and propafenone (○ 0 μm, ▪ 10 μm, ▴ 25 μm, • 50 μm) (b) in microsomes from B-lymphoblastoid cells expressing human CYP1A2. Each data point represents the mean of duplicate determinations.
