Mean marimastat plasma concentration-time profiles following single oral administration of 25, 50, 100, 200, 400 or 800 mg of marimastat to male volunteers. For clarity, error bars have not been included. Standard errors for Cmaxare representative; 16.4, 47.8, 44.7, 118.6, 149.3, and 164.7 for the 25 mg, 50 mg, 100 mg, 200 mg, 400 mg and 800 mg doses respectively.