Figure 2.

Pharmacokinetic profile of a single oral dose of terazosin (5 mg) in h.p.l.c. and radioreceptor analysis. Ten young, healthy, male subjects received a single oral dose of 5 mg terazosin. Before and 1, 3, 5, 7, 10 and 23.5 h after drug intake a blood sample was taken. Plasma derived from those samples was analyzed by h.p.l.c. and used in the radioreceptor assay. Drug levels are expressed as multiples of the concentration which occupies 50% of the human α_1A-, α_1B- or α_1D-adrenoceptor (i/K_i) as calculated according to equation (1). Data are median values from 10 subjects (filled circles) with upper and lower quartiles (dashed lines).