TABLE 3.
Consensus mutations in replicons isolated from HeLa and mouse hepatoma cell clones
| Cell clone | Conserved mutation(s) | NS protein |
|---|---|---|
| GS4.1 | E1202G | NS3 |
| S2204I, D2254E, I2324V | NS5A | |
| SL1 | Q1067R, S1128A, E1202G, S1323P, S1560Ga | NS3 |
| L1701F | NS4A | |
| Q1720R, Q1727H, V1749A, V1893L | NS4B | |
| T2035A, S2204I, I2252V, D2254E, I2274V, R2290L, I2324V, del.2371-2413b | NS5A | |
| W2990R | NS5B | |
| SL2 | I1097V, Q1112R, P1115L, V1593M, M1647I | NS3 |
| L1715P, Q1737R, V1749A, I1797V, N1965Y | NS4B | |
| Q2012L, S2204I, E2247G, D2254E, K2302R, I2324V, S2336P, L2400S, E2411G, A2412V | NS5A | |
| MH1 | Q1067R, S1128A, E1202G, S1323P, S1560G | NS3 |
| Q1720R, Q1727H, V1749A, V1893L | NS4B | |
| T2035A, S2204I, I2252V, D2254E, I2274V, R2290L, I2324V, M2388T, T2496A | NS5A | |
| W2990R | NS5B | |
| MH2 | Q1112R, E1202G,a S1323P, S1560G | NS3 |
| L1701F | NS4A | |
| Q1720R, Q1727H, V1749A, V1893L | NS4B | |
| T2035A, T2185A, S2204I, I2252V, D2254E, I2274V, R2290,a I2324Va | NS5A | |
| W2990Ra | NS5B | |
| MH4 | Q1067R, S1128A, E1202G, S1323P, S1560G | NS3 |
| L1701F | NS4A | |
| Q1720R, Q1727H, V1749A, V1893L, A1841T | NS4B | |
| T2035A, S2204I, I2252V, D2254E, I2274V, R2290L, I2324V, T2364M, L2391R | NS5A | |
| I2843V, W2990R | NS5B |
a
Mutation that occurred in 50% of the clones analyzed.
b
del., deletion.