Table 3.
Mean pharmacokinetic parameters for sildenafil and UK-103,320. Geometric means reported for AUC6 and Cmax, arithmetic means reported for tmax and plasma protein binding.
| Parameter | Sildenafil±s.d. | UK-103,320±s.d. |
|---|---|---|
| AUC6 (ng ml−1 h) | 841±293 | 341±157 |
| Cmax (ng ml−1) | 331±115 | 125±59 |
| tmax (h) | 1.40±0.49 | 1.44±0.65 |
| Plasma protein binding (% free) | ||
| 1 h after dose | 5.71±2.25 | 6.87±2.65 |
| 4 h after dose | 4.71±1.64 | 5.50±1.65 |
Cmax = Maximum observed plasma concentration; tmax = time to achieve maximum observed plasma concentration; AUC6 = area under the plasma concentration–time curve from zero time to the last measured concentration.