Table 3.

Individual and mean plasma pharmacokinetics of sildenafil, UK-103,320 and UK-150,564 following IV administration of 25-mg sildenafil.

Parameter	Sildenafil	UK-103,320	UK-150,564
Cmax (ng ml−1)
Subject 1	455	41	31
Subject 2	565	32	15
Subject 3	540	43	15
Geometric Mean	518	38	19
AUC (ng h ml−1)
Subject 1	928	119	124
Subject 2	1051	136	76
Subject 3	939	198	67
Geometric Mean	971	147	86
Tmax (h)
Subject 1	0.42	0.75	0.75
Subject 2	0.42	1.00	0.75
Subject 3	0.42	0.75	1.00
Arithmetic Mean	0.42	0.83	0.83
t1/2 (h)
Subject 1	1.69	1.97	7.24
Subject 2	3.61	2.86	7.32
Subject 3	1.96	2.18	3.59
Harmonic Mean	2.18	2.28	5.42