Table 1.
Demographics and biochemistry at baseline.
| Mean±s.d./Count | Range | Count (%) | |
|---|---|---|---|
| n | 1335 | ||
| Age (y) | 57.7±10.2 | 19–87 | |
| Weight (kg) | 86.6±14.1 | 49–159 | |
| Race | |||
| White | 1240 | 92.9 | |
| Black | 53 | 3.9 | |
| Asian | 14 | 1.0 | |
| Other | 29 | 2.2 | |
| ED aetiology | |||
| Organic | 786 | 58.9 | |
| Psychogenic | 211 | 15.8 | |
| Mixed | 338 | 25.3 | |
| Biochemical parameters | |||
| Serum creatinine (mg dl−1) | 0.98±0.19 | 0.20–2.23 | |
| Albumin (g dl−1) | 4.37±0.27 | 3.40–5.38 | |
| Bilirubin (µmol l−1) | 0.66±0.27 | 0.20–2.39 | |
| AST (IU l−1) | 24.1±8.0 | 9–91 | |
| ALT (IU l−1) | 27.7±13.0 | 6–124 | |
| Alkaline phosphatase (IU l−1) | 81.0±24.7 | 18–315 | |
| Alcohol consumption (units per week)* | |||
| none | 400 | 29.9 | |
| 1–15 | 542 | 40.6 | |
| 16–30 | 174 | 13.0 | |
| >30 | 220 | 16.5 | |
| Smokers | 297 | 22.2 | |
| Concomitant medications | |||
| Thiazide and related diuretics | 36 | 2.7 | |
| Loop and potassium-sparing diuretics | 31 | 2.3 | |
| ACE-I and angiotensin II antagonists | 177 | 13.3 | |
| Calcium channel blockers | 151 | 11.3 | |
| ‘Cardioselective’ β-blockers† | 64 | 4.8 | |
| ‘Noncardioselective’ β-blockers‡ | 35 | 2.6 | |
| CYP2C9 potential inhibitors§ | 115 | 8.6 | |
| CYP3A4 potential inhibitors∥ | 214 | 16.0 | |
| CYP2D6 potential inhibitors¶ | 136 | 10.2 | |
| CYP450 potential inducers# | 31 | 2.3 | |
ED=erectile dysfunction; AST=aspartate transaminase; ALT=alanine transaminase; ACE-I=angiotensin-converting enzyme inhibitor
one unit is equivalent to one glass of wine
classified as atenolol, betaxolol, bisoprolol, metoprolol, acebutolol
classified as propranolol, carteolol, carvedilol, celiprolol, esmolol, labetolol, levobunolol, metipranolol, nadolol, oxprenolol, pindolol, sotalol, timolol
classified as nonsteroidal anti-inflammatory drugs, tolbutamide, warfarin
classified as verapamil, diltiazem, nicardipine, chloramphenicol, erythromycin, azithromycin, clarithromycin, allopurinol, sodium valproate, cimetidine, metronidazole, dextropropoxyphene, nitrendipine, dextromethorphan, nifedipine, ergotamine, felodipine, tamoxifen, cyclosporin, ketoconazole, fluconazole, itraconazole, miconazole, danazol, sulindac, acetazolamide, colchicine, metoclopraide, glucocorticoids, hypnotics, anxiolytics, methadone, isoniazid, amiodarone, terfenadine, quinidine
classified as antimalarials, selective serotonin reuptake inhibitors, tricyclic and related antidepressants, antipsychotics
-blockers, quinidine, timolol
classified as barbiturates, carbamazepine, phenytoin, griseofulvin, rifampicin, phenylbutazone, omeprazole, sulphadimidine, trimethoprim.