Table 3.

Interaction between covariates in the final population pharmacokinetic model and the influence of covariate combinations on CL/F.

	10		30		50		70		90
AST (IU l−1) CYP3A4 (yes/no)	no	yes	no	yes	no	yes	no	yes	no	yes
Age (y)	CL/F (l h−1)
20	69	60	61	53	53	46	45	39	37	32
40	65	56	57	49	50	43	42	36	34	30
60	60	52	53	46	46	40	39	34	32	28
80	56	48	49	42	43	37	36	31	30	26

CL/F=apparent clearance; AST=aspartate transaminase.