Table 1.
Pharmacokinetic parameters of sildenafil following intravenous (IV) or oral (PO) administration of 50-mg sildenafil. Geometric mean data are presented for AUC, AUCt and Cmax, arithmetic means are presented for tmax, kel, CL, V and Vss, and harmonic means are presented for t1/2. Absolute oral bioavailability (F) was calculated from the ratio of AUC geometric means following oral/intravenous administration. n = 12 per group.
| Parameter | IV | PO |
|---|---|---|
| AUC (ng ml−1 h) | 1291 | 530 |
| AUCt (ng ml−1 h) | 1289 | 528 |
| Cmax (ng ml−1) | 531 | 159 |
| tmax (h) | 0.73 | 1.46 |
| kel (h−1) | 0.18 | 0.17 |
| t1/2 (h) | 3.92 | 4.07 |
| CL (l h−1) | 40.8 | – |
| V (l) | 234 | – |
| Vss (l) | 105 | – |
| F (90% CI) | 41% (35.6–47.3) | |