Table 2.

Pharmacokinetic parameters of sildenafil and UK-103,320 following administration of 100-mg sildenafil in the fed or fasted state. Geometric means are presented for AUC, AUC_t and C_max, arithmetic means are presented for t_max and k_el and harmonic means are presented for t_1/2. Fed:fasted ratios for AUC and C_max were derived from comparing the geometric means for these parameters. n = 34 per group.

	Sildenafil		UK-103,320
Parameter	Fed	Fasted	Fed	Fasted
AUC (ng ml−1 h)	1489	1670	571	729
Fed:fasted AUC ratio (90% CI)	0.89 (84–94)
AUCt (ng ml−1 h)	1465	1651	547	700
Cmax (ng ml−1)	364*	514	137	215
Fed:fasted Cmax ratio (90% CI)	0.71 (62–81)
tmax (h)	2.04*	0.95	1.94	0.90
kel (h−1)	0.16†	0.17	0.11	0.12
t1/2 (h)	4.33†	3.98	6.1	5.94

^*P <0.001

^†P <0.05 compared to fasted group.