Table 3.

Pharmacokinetic parameters of sildenafil and UK-103,320 following administration of single oral doses of sildenafil ranging from 25 to 200 mg (dose-proportionality study). Geometric means are presented for AUC, AUC_t and C_max, arithmetic means are presented for t_max and k_el and harmonic means are presented for t_1/2. n = 32 per group.

	25 mg	50 mg	100 mg	200 mg
Sildenafil
AUC (ng ml−1 h)	361*	738	1685	3755
AUCt (ng ml−1 h)	334	727	1667	3702
Cmax (ng ml−1)	127	271	560	1150
tmax (h)	1.02	0.79	0.83	0.94
kel (h−1)	0.26*	0.23	0.19	0.18
t1/2 (h)	2.62	2.96	3.73	3.84
UK-103,320
AUC (ng ml−1 h)	147*	328	776	1822
AUCt (ng ml−1 h)	134	318	756	1772
Cmax (ng ml−1)	54	126	254	526
tmax (h)	0.97	0.78	0.77	0.88
kel (h−1)	0.24*	0.20	0.15	0.14
t1/2 (h)	2.85*	3.48	4.57	4.85

^*n = 30 per group.