Table 2.
Mean pharmacokinetic parameters for sildenafil and UK-103,320 on days 1 and 6 in the erythromycin study. Geometric means are presented for AUC and Cmax, arithmetic means are presented for Tmax and kel and harmonic means are presented for t1/2.
| Group 1 | Group 2 | |||
|---|---|---|---|---|
| Parameter | Day 1 Sildenafil | Day 6 Sildenafil+ Erythromycin | Day 1 Sildenafil | Day 6 Sildenafil+ Placebo |
| Sildenafil | ||||
| AUC, (ng ml−1 h) (range) | 1904 (1336–3073) | 4911 (3184–9376) | 1893 (1358–3396) | 1732 (931–2815) |
| Cmax (ng ml−1) (range) | 596 (373–1292) | 1245 (831–1833) | 639 (462–1016) | 512 (327–727) |
| Tmax (h) (range) | 1.06 (0.25–3.00) | 0.79 (0.50–1.50) | 1.00 (0.50–3.00) | 1.17 (0.50–3.00) |
| kel (h−1) (range) | 0.20 (0.18–0.26) | 0.17 (0.11–0.20) | 0.21 (0.15–0.31) | 0.20 (0.15–0.29) |
| t1/2 (h) (range) | 3.47 (2.69–3.91) | 4.06 (3.51–6.29) | 3.26 (2.25–4.54) | 3.48 (2.36–4.53) |
| UK-103,320 | ||||
| AUC (ng ml−1 h) (range) | 905 (549–2349) | 1099 (508–2310) | 867 (463–1946) | 769 (435–1551) |
| Cmax (ng ml−1) (range) | 270 (151–489) | 169 (76–290) | 277 (163–379) | 227 (144–296) |
| Tmax (h) (range) | 1.13 (0.50–3.00) | 0.88 (0.50–1.00) | 0.92 (0.50–2.00) | 1.17 (0.50–3.00) |
| kel (h−1) (range) | 0.16 (0.09–0.28) | 0.13 (0.07–0.18) | 0.18 (0.14–0.24) | 0.19 (0.12–0.36) |
| t1/2 (h) (range) | 4.22 (2.52–7.55) | 5.30 (3.81–10.14) | 3.91 (2.84–5.11) | 3.61 (1.92–5.86) |