Table 3.
Mean pharmacokinetic parameters for sildenafil and UK-103,320 on days 1 and 4 in the azithromycin study. Geometric means are presented for AUC and Cmax, arithmetic means are presented for Tmax and kel and harmonic means are presented for t1/2.
| Group 1 | Group 2 | |||
|---|---|---|---|---|
| Parameter | Day 1 Sildenafil | Day 4 Sildenafil+ Azithromycin | Day 1 Sildenafil | Day 4 Sildenafil+ Placebo |
| Sildenafil | ||||
| AUC (ng ml−1 h) (range) | 1327 (929–2012) | 1216 (536–1676) | 1423 (1011–2311) | 1242 (804–2121) |
| Cmax (ng ml−1) (range) | 453 (257–843) | 526 (155–804) | 459 (264–869) | 403 (250–633) |
| Tmax (h) (range) | 1.15 (0.25–3.00) | 0.79 (0.50–2.00) | 0.96 (0.50–2.00) | 0.96 (0.50–2.00) |
| kel (h−1) (range) | 0.15 (0.11–0.18) | 0.15 (0.11–0.20) | 0.15 (0.11–0.21) | 0.16 (0.11–0.24) |
| t1/2 (h) (range) | 4.53 (3.79–6.14) | 4.50 (3.07–6.58) | 4.53 (3.23–6.57) | 4.28 (3.14–6.20) |
| UK-103,320 | ||||
| AUC (ng ml−1 h) (range) | 665 (368–1148) | 639 (403–1065) | 586 (353–1195) | 537 (395–920) |
| Cmax (ng ml−1) (range) | 194 (85–324) | 234 (186–284) | 181 (104–457) | 172 (112–382) |
| Tmax (h) (range) | 1.04 (0.50–2.00) | 0.79 (0.50–2.00) | 0.88 (0.50–1.50) | 0.88 (0.50–2.00) |
| kel (h−1) (range) | 0.11 (0.08–0.20) | 0.15 (0.11–0.27) | 0.11 (0.08–0.14) | 0.15 (0.10–0.26) |
| t1/2 (h) (range) | 6.37 (3.46–10.18) | 4.59 (2.58–6.28) | 6.43 (4.78–9.16) | 4.57 (2.69–6.94) |