Table 2.
Observed (Obs) and expected (Exp) number and O/E ratios of UGIB associated with current and former NSAID use among persons with at least one NSAID prescription recorded in the North Jutland County Pharmaco-Epidemiologic Prescription Database, 1991–95. Exposure window is 90 days for all drugs considered.
| Periods of drug use | Number of persons | Person-years | Obs | UGIB Exp | O/E | 95% CI |
|---|---|---|---|---|---|---|
| Current use of NSAID | 156 138 | 107 305 | 515 | 124.9 | 4.12 | 3.8, 4.5 |
| NSAID only | 152 882 | 94 987 | 365 | 101.2 | 3.61 | 3.3, 4.0 |
| NSAID+glucocorticoids | 17 875 | 5908 | 58 | 8.0 | 7.24 | 5.5, 9.4 |
| NSAID+glucocorticoids+other drug (not anticoagulants) | 1593 | 464 | 7 | 1.1 | 6.41 | 2.6, 13.2 |
| NSAID+anticoagulants | 1001 | 340 | 8 | 0.7 | 11.46 | 4.9, 22.6 |
| NSAID+anticoagulants+other drug (not glucocorticoids) | 178 | 35 | 0 | 0.1 | – | – |
| NSAID+glucocorticoids+anticoagulants±other drugs | 154 | 29 | 1 | 0.1 | 18.74 | 0.2, 10.4 |
| NSAID±lowdose aspirin±highdose aspirin | 10 246 | 5542 | 76 | 13.8 | 5.52 | 4.3, 6.9 |
| Former use of NSAID | 145 8771 | 314 278 | 370 | 264.4 | 1.40 | 1.3, 1.5 |
| Non use of any other drug2 | 144 584 | 294 676 | 267 | 224.9 | 1.19 | 1.0, 1.3 |
| Current use of other drug2 (not NSAID) | 28 455 | 19 602 | 103 | 39.6 | 2.60 | 2.1, 3.2 |
1
Among the 156 138 NSAID users, 145 877 were followed during periods of non use 90 or more days after a nonrenewed prescription.
2
The category includes drugs suspected to predispose to UGIB (low-and high dose aspirin, anticoagulants and glucocorticoids).