Table 5.
Observed (Obs) and expected (Exp) numbers and O/E ratios of UGIB during periods of use of naproxen without use of other drugs according to sex, age, number of naproxen prescriptions and dose of naproxen. Exposure window is 90 days.
| Characteristics | Number of persons | Person-years | Obs | UGIB Exp | O/E | 95% CI |
|---|---|---|---|---|---|---|
| Users with at least one naproxen prescription | 30 033 | |||||
| Sex | ||||||
| Men | 12 298 | 4682 | 11 | 5.3 | 2.06 | 1.0, 3.7 |
| Women | 17 735 | 8130 | 24 | 6.2 | 3.86 | 2.5, 5.7 |
| Age (years) | ||||||
| < 60 | 22 538 | 8625 | 8 | 2.3 | 3.45 | 1.5, 6.8 |
| 60–69 | 3255 | 1648 | 5 | 1.5 | 3.25 | 1.0, 7.6 |
| > 69 | 4240 | 2538 | 22 | 7.7 | 2.86 | 1.8, 4.3 |
| Number of prior naproxen prescriptions | ||||||
| 0 | 22 984 | 4616 | 8 | 2.7 | 3.01 | 1.3, 5.9 |
| 1 | 11 347 | 2081 | 2 | 1.5 | 1.34 | 0.2, 4.8 |
| 2 | 6982 | 1235 | 4 | 1.0 | 3.85 | 1.0, 9.9 |
| 3 | 4819 | 822 | 3 | 0.8 | 3.86 | 0.8, 11.3 |
| 4 | 3643 | 604 | 1 | 0.6 | 1.63 | 0.0, 9.1 |
| 5 + | 4242 | 3455 | 17 | 5.0 | 3.43 | 2.0, 5.5 |
| Users with at least three consecutive naproxen prescriptions | 3530 | |||||
| Dose of naproxen (mg day−1) | ||||||
| < 700 | 2208 | 1228 | 6 | 1.8 | 3.26 | 1.2, 7.1 |
| 700–1199 | 1538 | 962 | 6 | 1.4 | 4.18 | 1.5, 9.1 |
| ≥ 1200 | 608 | 279 | 2 | 0.5 | 4.37 | 0.5, 15.8 |