Table 2.

Plasma concentration of F1 +2 (nM) expressed as the median (and range) in the placebo group and in the two groups of patients given 0.5 and 3 mg h−1 S 18326, respectively.

	Subjects	Before infusion (t0)	End of infusion (t24 h)	t36 h
Placebo group	6	0.66	0.68	0.65
		(0.54–0.99)	(0.52–0.88)	(0.49–1.00)
0.5 mg h−1	10	0.83	0.60*	0.62
		(0.52–1.15)	(0.41–0.89)	(0.46–2.18)
3 mg h−1	20	0.80	0.44**	0.62**
		(0.48–1.10)	(0.27–0.79)	(0.36–0.98)

Wilcoxon test, within-group comparison vs t0:

^*P < 0.05,

^**P < 0.01.