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. 2002 Feb;53(2):111–122. doi: 10.1046/j.0306-5251.2001.01548.x

Figure 5.

Figure 5

Relationship between the CYP2D6 genotype and the plasma concentration-to-dose (C/D) ratios of risperidone (left) and the active moiety of risperidone (risperidone plus 9-hydroxyrisperidone, right). UM=ultrarapid metabolizers, defined as a carrier of gene duplication; EM homozygous=extensive metabolizers homozygous for the functional CYP2D6*1 allele; EM heterozygous=EM heterozygous for a defective CYP2D6 gene; PM=poor metabolizers carrying two defect genes. Reproduced with permission from Scordo et al.[38].