Table 1.
Pharmacokinetic parameters for norelgestromin.
| Parameter | Abdomen | Arm | Buttock | Torso |
|---|---|---|---|---|
| Cmax, (ng ml−1)* | 0.88 (0.28) | 1.18 (0.35) | 1.17 (0.50) | 1.07 (0.38) |
| Median tmax (interquartile range) (h)* | 72 (48–72) | 72 (48–72) | 72 (48–72) | 72 (48–72) |
| Css(48, 168 h) (ng ml−1)* | 0.78 (0.25) | 1.02 (0.27) | 0.99 (0.38) | 0.95 (0.32) |
| AUC(0, 168 h) (ng ml−1 h)* | 117 (37.6) | 155 (44.3) | 150 (57.9) | 143 (50.4) |
| AUC(0, 240 h) ng ml−1 h)* | 136 (43.6) | 177 (46.4) | 174 (64.6) | 166 (56.7) |
| t½, (h)† | 27.6 (10.4) | 26.1 (7.0) | 28.0 (6.9) | 30.1 (21.4) |
Values presented are means (s.d.) unless otherwise stated.
*
n = 33, 32, 36, and 35 for abdomen, arm, buttock, and torso, respectively.
†
n=32, 31, 35, and 33 for abdomen, arm, buttock, and torso, respectively.