Table 2.
Pharmacokinetic parameters for ethinyloestradiol.
| Parameter | Abdomen | Arm | Buttock | Torso |
|---|---|---|---|---|
| Cmax (pg ml−1)* | 58.7 (19.9) | 69.5 (20.6) | 66.3 (23.9) | 71.2 (32.2) |
| Median tmax (interquartile range) (h)* | 48 (48–72) | 48 (48–72) | 48 (36–48) | 48 (48–72) |
| Css(48, 168 h) (pg ml−1)* | 46.6 (14.0) | 57.0 (14.9) | 54.0 (16.5) | 57.1 (20.3) |
| AUC(0, 168 h) (pg ml−1 h)* | 7163 (2211) | 8751 (2272) | 8391 (2622) | 8599 (3161) |
| AUC(0, 240 h) (pg ml−1 h)* | 7766 (2332) | 9540 (2437) | 9189 (2755) | 9523 (3354) |
| t½ (h)† | 16.1 (3.0) | 16.4 (3.5) | 18.1 (6.4) | 17.1 (3.8) |
Values presented are means (s.d.) unless otherwise stated.
*
n = 33, 32, 36, and 35 for abdomen, arm, buttock, and torso, respectively.
†
n = 31, 32, 35, and 33 for abdomen, arm, buttock, and torso, respectively.