Table 2.

Number of adverse events per subject during multiple dosing for 35 or 56 days for those events with a frequency ≥0.5 in one dose group.

	Multiple dose (Number of subjects with advise event)
	Placebo	20 mg (n = 6)	40 mg (n = 12)	80 mg (n = 18)	160 mg (n = 6)
Headache	1.1 (7)	1.7 (5)	0.8 (5)	0.4 (4)	2.5 (5)
Abdominal pain	0.1 (2)	0.2 (1)	0.6 (6)	0.7 (6)	1.7 (3)
Pharyngitis	0.2 (3)	0.2 (2)	0.4 (5)	0.2 (4)	0.5 (3)
Fatigue	–	–	0.3 (4)	0.1 (2)	0.5 (2)
Nausea	0.1 (1)	–	0.3 (3)	0.2 (2)	0.5 (2)
Hot flushes	0.3 (2)	–	0.6 (5)	0.1 (2)	0.2 (1)
Leukorrhea	–	0.2 (1)	0.3 (4)	0.2 (3)	1.0 (5)
Myalgia	0.1 (1)	0.5 (3)	0.2 (1)	0.1 (1)	–
Number of adverse events per subject	4.0	5.0	7.4	4.3	11.8