. 2002 Mar;53(3):284–295. doi: 10.1046/j.0306-5251.2001.01181.x

Table 4.

Mean of baseline and mean of absolute change in collagen I C-telopeptide, total alkaline phosphatase, triglycerides, total cholesterol, LDL-cholesterol, HDL-cholesterol, FSH, and LH after 35 or 56 days of treatment with levomeloxifene.

	Baseline values and absolute change from baseline
	Day 35 (Part 1)				Day 56 (Part 2)
	Placebo (n = 6)	20 mg (n = 6)	80 mg (n = 6)	160 mg (n = 6)	Placebo (n = 8)	40 mg (n = 12)	80 mg (n = 12)
C-telopeptide^* (µg mmol⁻¹)	365	250	379	313	333	441	321
	−25.1	−135	−191	−166	−50.6	−208	−139
Alkaline phosphatase^** (U l⁻¹)	66.3	66.3	61.8	85.5	62.4	78.2	72.3
	0.6	−5.2	−6.6	−21.7	−2.8	−24.3	−21.3
Triglycerides^*** (mmol l⁻¹)	1.33	1.17	0.99	1.53	1.09	1.54	1.19
	0.00	0.18	0.20	−0.03	0.11	−0.03	−0.04
Total cholesterol^** (mmol l⁻¹)	6.18	5.53	5.70	6.55	5.74	6.13	6.10
	−0.04	−1.12	−1.32	−1.62	0.21	−1.41	−1.37
LDL-cholesterol^** (mmol l⁻¹)	4.23	3.47	3.60	4.37	3.44	3.84	3.84
	−0.03	−1.05	−1.19	−1.39	0.14	−1.23	−1.23
HDL-cholesterol^*** (mmol l⁻¹)	1.35	1.53	1.65	1.48	1.81	1.59	1.73
	0.00	−0.15	−0.22	−0.22	0.01	−0.17	−0.17
FSH^** (IU l⁻¹)	66.4	59.3	67.7	72.0	63.7	77.2	85.0
	1.00	−26.7	−23.4	−35.6	−3.83	−42.3	−45.5
LH^** (IU l⁻¹)	25.9	27.3	35.2	23.6	24.2	39.3	30.9
	1.82	−13.2	−15.5	−9.78	0.64	−21.3	−12.5

statistical significant difference between active and placebo after 56 days of treatment, P < 0.015, F-test with 2 d.f.

^**

statistical significant difference between active and placebo after 35 days and after 56 days of treatment, P < 0.05.

^***

not statistically significant after 35 days nor after 56 days of treatment, P > 0.05.