Table 5.
Pharmacokinetic parameters for levormeloxifene after administration of single oral doses. Data are presented as mean (± s.d.). NA: insufficient data for estimation of AUC and t1/2; Numbers in brackets represent the range. The final eight (or more) sampling points were used for the estimation of λz.
| Levormeloxifene dose | ||||||
|---|---|---|---|---|---|---|
| 2.5 mg | 10 mg | 30 mg | 80 mg | 160 mg | 320 mg | |
| Cmax (ng ml−1) | 5.6 ± 1.3 | 27 ± 6.2 | 128 ± 42 | 443 ± 94 | 1115 ± 180 | 2737 ± 607 |
| tmax (h) | 2.50 ± 2.07 | 2.67 ± 1.03 | 2.50 ± 1.22 | 1.50 ± 0.55 | 2.00 ± 1.10 | 2.0 ± 0.02 |
| t1/2* (days) | NA | 8.4 (6.0–10.4) | 6.9 (4.7–8.8) | 5.8 (4.6–6.6) | 5.4 (3.6–8.2) | 6.0 (4.5–9.0) |
| AUC (µg ml−1 h) | NA | 3.2 ± 0.6 | 10 ± 2.8 | 26 ± 3.1 | 64 ± 21 | 129 ± 35 |
*
harmonic mean+(min-max).