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Properties of reovirus pathogenesis attributable to σ1 protein
| Viral serotype | Functional property
|
||||
|---|---|---|---|---|---|
| Intestinal growth | Pathway of spread | CNS tropism | Tail receptor | Head receptor | |
| 1 | Yes | Hematogenous | Ependymal cells | Unknown carbohydrate | JAM1 |
| 3 | Variablea | Neural | Neurons | Sialic acid | JAM1 |
Some type 3 reovirus strains can infect the intestine and disseminate systemically. Others fail to infect intestinal tissue and do not spread to distant sites.
