Table 2.

Monitoring of plasma NSAIDs concentrations after oral intake of 75 mg day⁻¹ of diclofenac SR, 400 mg three times daily of ibuprofen and 7.5 mg day⁻¹ of meloxicam. H.p.l.c. analysis was done as described in the method section. Concentration was determined 3.5 h after diclofenac, 2.5 h after ibuprofen and 5.5 h after meloxicam intake and steady-state was evaluated after 3 days of diclofenac, 2 days of ibuprofen and 5 days of meloxicam. Data are expressed as mean ± s.d. of 24 volunteers.

Diclofenac (µg ml−1) ([µm])		Ibuprofen (µg ml−1) ([µm])		Meloxicam (µg ml−1) ([µm])
Single	Repeated	Single	Repeated	Single	Repeated
0.38 ± 0.35	0.27 ± 0.18	24.0 ± 8.0	14.8 ± 5.9	0.62 ± 0.13	1.09 ± 0.37*
[1.19 ± 1.10]	[0.85 ± 0.57]	[116.2 ± 38.7]	[70.4 ± 1.28]	[1.76 ± 0.37]	[3.11 ± 1.06]*

^*P < 0.05 vs single intake.