Table 1.
Mefloquine population pharmacokinetic parameters for the final models where adjusting for body weight gave improved fits.
| Combined therapy and single dosing (74 patients) Estimate (s.e.) | 90% prediction intervals | Combined therapy and split dosing (31 patients) Estimate (s.e.) | 90% prediction intervals | |
|---|---|---|---|---|
| CL/F (l day−1)* | 33.0 (2.4) | 14.9, 73.3 | 23.8 (2.2) | 12.9, 43.9 |
| Change in CL/F (l day−1) for anincrease of 1 kg in body weight | 1.6 (0.3) | 0.9 (0.3) | ||
| V/F (l)* | 383.9 (18.3) | 220.50, 668.24 | 330.6 (19.2) | 217.4, 502.9 |
| Change in V/F (l) for an increase of 1 kg in body weight | 15.2 (2.1) | 11.9 (2.7) | ||
| ke (elimination rate)* | 0.09/day | 0.07/day | ||
| t½ (elimination half life)* | 8.1 days | 9.6 days | ||
| σε (ng ml−1) | 295.6 | 259.2 |
*
For a person having a mean body weight; s.e., standard error.