Table 2.
Pharmacokinetic parameters.
| Cmax (ng ml−1) | AUC (ng ml−1 h) | Clearance (ml min−1) | Vss (l) | t1/2 (min) | |
|---|---|---|---|---|---|
| 600 µg dose | |||||
| Mean | 4.31 | 268.8 | 2285.3 | 250.9 | 163.5 |
| s.e. mean | 2.5 | 27.6 | 259.8 | 50.7 | 39.2 |
| n | 3 | 3 | 3 | 3 | 3 |
| % CV | 1.0 | 0.17 | 0.19 | 0.35 | 0.41 |
| High | 9.31 | 303.9 | 2801.4 | 344.0 | 234.3 |
| Low | 1.21 | 214.1 | 1973.9 | 169.5 | 98.7 |
| 750 µg dose | |||||
| Mean | 6.09 | 485.1 | 1723.5 | 289.0 | 179.6 |
| s.e. mean | 1.6 | 98.5 | 437.7 | 30.6 | 20.7 |
| n | 3 | 3 | 3 | 3 | 3 |
| % CV | 0.46 | 0.35 | 0.43 | 0.18 | 0.20 |
| High | 7.7 | 595.9 | 2598.3 | 327.0 | 201.4 |
| Low | 2.81 | 288.6 | 1258.4 | 228.3 | 138.0 |
| 1000 µg dose | |||||
| Mean | 4.3 | 653.5 | 1590.5 | 383.0 | 184.8 |
| s.e. mean | 0.8 | 84.4 | 234.3 | 60.3 | 8.4 |
| n | 3 | 3 | 3 | 3 | 3 |
| % CV | 0.32 | 0.22 | 0.25 | 0.27 | 0.07 |
| High | 5.9 | 754.9 | 2057.7 | 503.4 | 195.2 |
| Low | 3.22 | 719.7 | 1324.5 | 315.2 | 168.0 |
| 1250 µg dose | |||||
| Mean | 12.8 | 863.5 | 1515.0 | 266.9 | 143.4 |
| s.e. mean | 2.3 | 137.5 | 212.9 | 43.2 | 7.7 |
| n | 3 | 3 | 3 | 3 | 3 |
| % CV | 0.32 | 0.27 | 0.24 | 0.28 | 0.09 |
| High | 17.3 | 1135.5 | 1807.5 | 353.0 | 151.5 |
| Low | 12 | 691.5 | 1100.8 | 216.8 | 127.8 |
| 2000 µg dose | |||||
| Mean | 8.8 | 1352.1 | 1554.3 | 375.3 | 172.3 |
| s.e. mean | 2.8 | 195.4 | 260.6 | 70.3 | 9.0 |
| n | 3 | 3 | 3 | 3 | 3 |
| % CV | 0.55 | 0.25 | 0.29 | 0.32 | 0.09 |
| High | 14.5 | 1587.3 | 2074.2 | 515.1 | 187.8 |
| Low | 5.09 | 1505.0 | 1259.9 | 291.9 | 156.4 |
| Dose group | |||||
| 600 µg | 4.31 | 269 | 2285 | 251 | 164 |
| 750 µg | 6.10 | 485 | 1724 | 289 | 180 |
| 1000 µg | 4.32 | 654 | 1591 | 383 | 185 |
| 1250 µg | 12.82 | 864 | 1515 | 267 | 143 |
| 2000 µg | 8.88 | 1352 | 1554 | 375 | 172 |