Table 3.
Comparison of allele frequencies of CYP2C19 reported from different ethnic populations.
| Frequency (P value vs Egyptians) | |||||
|---|---|---|---|---|---|
| Population | n | *1 | *2 | *3 | Reference |
| Egyptians | 494 | 0.888 | 0.110 | 0.002 | Present study |
| Caucasians | |||||
| American | 210 | 0.871 | 0.129 (NS) | 0 (NS) | [35] |
| Canadian (Inuit) | 304 | 0.890 | 0.110 (NS) | 0 (NS) | [36] |
| Danish | 478 | 0.839 | 0.161 (0.0200) | 0 (NS) | [37] |
| Swedish | 166 | 0.849 | 0.144 (NS) | 0.007 (NS) | [38] |
| German | 280 | 0.850 | 0.150 (NS) | 0 (NS) | [39] |
| Portuguese | 306 | 0.870 | 0.130 (NS) | 0 (NS) | [40] |
| Australian | 198 | 0.854 | 0.146 (NS) | 0 (NS) | [41] |
| Saudi Arabia | 194 | 0.850 | 0.150 (NS) | 0 (NS) | [35] |
| Asians | |||||
| Japanese | 106 | 0.670 | 0.230 (0.0022) | 0.104 (<0.0001) | [35] |
| Korean | 206 | 0.675 | 0.209 (0.0008) | 0.116 (<0.0001) | [42] |
| Chinese-Taiwanese | 236 | 0.630 | 0.320 (<0.0001) | 0.055 (<0.0001) | [35] |
| Filipino | 104 | 0.540 | 0.390 (<0.0001) | 0.077 (<0.0001) | [35] |
| South-west Asia | |||||
| North Indian | 242 | 0.700 | 0.300 (<0.0001) | 0 (NS) | [43] |
| Africans | |||||
| Bantu-Tanzanian | 502 | 0.815 | 0.179 (0.0021) | 0.006 (NS) | [42] |
| Ethiopian | 228 | 0.846 | 0.136 (NS) | 0.018 (0.0400) | [44] |
| Venda | 304 | 0.783 | 0.217 (<0.0001) | 0 (NS) | [45] |
| Zimbabwean | 336 | 0.869 | 0.131 (NS) | 0 (NS) | [45] |
| African-Americans | 216 | 0.750 | 0.250 (<0.0001) | 0 (NS) | [35] |
n, total number of alleles.
Differences in allele frequencies were measured by Fisher exact test.
NS indicates that there were no significant differences (P>0.05).