Table 4.

Precision of the limited sampling designs assessed on validation set.

Design number	Timing of samples (h)	CL	MAE (%) t1/2
Three blood samples
1	end inf*, 1 and 24 h	8.0	11.5
2	0.67**, 1 and 24 h	8.7	11.6
3	end inf, 3 and 24 h	6.8	11.0
4	0.67, 3 and 24 h	7.7	10.2
5	end inf, 6 and 24 h	8.4	11.7
6	0.67, 6 and 24 h	8.0	10.2
Two blood samples
7	1 and 24 h	8.2	12.0
8	3 and 24 h	8.3	13.8
9	6 and 24 h	8.5	12.9

^*end inf: is actually collected just before the end of infusion (corresponding to 20 min after infusion start).

^**00.67 h corresponds to 20 min after the end of infusion.

MAE = Mean absolute error.