Table 5.

Estimates and precision of the population pharmacokinetic models for intravenous vinorelbine (from all 64 patients and 99 courses). CL_tot (l h⁻¹) = θ₁·BSA·(1−θ₂·Plt)+θ₃·Wt/Cr_s.V (l) = θ₄·(1−θ₅. Plt)·(1+θ₆·Gender).

	Covariate-free model		Final model
Parameter	Estimate	Precision CV (%)	Estimate	Precision CV (%)
CL (l h−1) θ1	39.4	5
BSA θ1			29.2	7
Plat θ2			0.00090	9
Wt/Crsθ3			6.70	37
V (l) θ4	2230	6	2340	10
Plat θ5			0.000849	7
Sex θ6			0.26	31
Vc (l)	20.9	6	19.5	5
β slope (h−1)	0.218	11	0.271	6
K21 (h−1)	0.434	7	0.471	6
K31 (h−1)	0.0321	6	0.0396	10
Inter-indiviual (IIV) and inter-occasion (IOV) CV (%)
IIV CL	30	26	21	19
IOV CL	10	43	5	63
IIV V	30	25	22	26
IIV Vc	31	30	26	45
IIV β	19	42	17	37
Correlation coefficient between inter-individual estimates
CL vs V	0.98	26	0.89	23
Residual CV (%)
σ	25	17	25	17
Objective function value	6998		6779