Table 1.
Comparison of pharmacokinetics of (S)-(+) and (R)-(−)-chlorpheniramine in extensive metabolizers in absence (Phase I) or presence (Phase II) of quinidine.
| (R)-(−)-chlorpheniramine | (S)-(+)-chlorpheniramine | |||||||
|---|---|---|---|---|---|---|---|---|
| Phase I | Phase II | aMean difference (95% CI) | aP value | Phase I | Phase II | aMean difference (95% CI) | aP value | |
| tmax (h) | 3.5 (2–4) | 3.0 (2–4) | 0.5 (−0.07, 1.1) | NS | 3.0 (2–4) | 3.0 (2–6) | −0.3 (−1.9,1.2) | NS |
| Cmax (ng ml−1) | 5.38±0.44 | 5.78±0.69 | −4.0 (−1.27, 0.47) | NS | 12.55±1.51 | 13.94±1.51 | −1.38 (−2.21, −0.56) | <0.01 |
| AUC(0,∞) (ng ml−1 h) | 124±24 | 224±41 | −100 (−158, −43) | <0.01 | 300±76 | 625±146 | −325 (−527, −124) | <0.01 |
| CLoral (l h−1 kg−1) | 1.07±0.15 | 0.60±0.10 | 0.47 (0.25, 0.68) | <0.005 | 0.49±0.08 | 0.22±0.03 | 0.27 (0.11, 0.43) | <0.01 |
| t½ (h) | 19.5±1.4 | 25.2±2.8 | −5.7 (−14.1, 2.7) | NS | 18.0±2.0 | 29.3±2.0 | −11.3 (−15.2, −7.4) | <0.001 |
NS, Not statistically significant. Data are mean values ±s.e. mean with the exception of tmax which is reported as median (range).
a
These values represent comparisons of Phase I and Phase II data.