Table 2.

Pharmacokinetics of (S)-(+) and (R)-(−)-chlorpheniramine in poor metabolizers.

	tmax (h)	Cmax (ng ml−1)	AUC(0,∞) (ng ml−1 h)	CLoral (l h−1 kg−1)
PM1 (R)-(−)-enantiomer
Phase I	8	5.61	412	0.24
Phase II	6	6.08	325	0.31
(S)-(+)-enantiomer
Phase I	3	14.85	1098	0.09
Phase II	6	13.01	600	0.17
PM2 (R)-(−)-enantiomer
Phase I	1	10.4	192	0.57
Phase II	3	5.59	164	0.67
(S)-(+)-enantiomer
Phase I	1	29.94	836	0.13
Phase II	2	14.23	630	0.17