Table 3.

Summary pharmacokinetics of R- and S-warfarin (n = 12 subjects).

	LSM entacapone	LSM placebo	Ratio entacapone/placebo(90% CI)
R-warfarin
Cmax (µg ml−1)	0.50	0.46	109 (102, 117)
tmax (h)a	1.0	1.0	+0.38b (0.00, 0.75)
AUCss (µg ml−1 h)	8.30	7.02	118 (111, 126)
S-warfarin
Cmax (µg ml−1)	0.61	0.60	102 (95, 109)
tmax (h)a	1.0	1.0	+0.25b (−0.25, + 0.50)
AUCss (µg ml−1 h)	10.9	10.4	105 (99, 110)

LSM = least squares means

^a= median value

^b= difference.