Table 2.
Change in clinical chemistry after 6 months therapy (mean (95% confidence interval)).
| Parameter | Change in placebo group (n = 12) | Change in metformin group (n = 9) | P value |
|---|---|---|---|
| Fasting glucose (mmol l−1) | −0.1 (−0.45, 0.001) | −0.2 (−0.4, 0.03) | 0.85 |
| Fasting insulin (mIU l−1) | −2.1 (−4.6,+4.0) | −1.5 (−4.8,+4.8) | 0.83 |
| Insulin resistance | −0.37 (−1.35,+1.50) | −0.60 (−1.35,+0.85) | 0.73 |
| β cell function | −29.17 (−44.1,+73.1) | +9.64 (−13.4,+67.7) | 0.73 |
| Testosterone (nmol l−1) | −0.15 (−0.33,+0.96) | +0.4 (−0.8,+0.3) | 0.17 |
| SHBG (nmol l−1) | +3 (−25.98,+14.6) | +4.5 (+0.33,+9.66) | 0.29 |
| Free androgen index | −2.3 (−29.5,+35.7) | −24.7 (−28.6,−4.3) | 0.36 |