Table 2.
Efficacy/pharmacodynamic results. Part I: dose-finding.
| Ttreatment A-I artemotil 3.2/1.6×4 | Treatment B-I artemotil 1.6/0.8×4 | Treatment C-I artemotil 3.2/0.8×4 | |
|---|---|---|---|
| PCT (h) | n = 8 | n = 6 | n = 9 |
| Median (range) | 32 (24–52) | 50 (28–132) | 32 (24–52) |
| PCT99% (h) | n = 8 | n = 6 | n = 9 |
| Mean (range) | 25.5 (16–41) | 39.6 (9–92) | 24.5 (20–30) |
| FCT (h) | n = 8 | n = 6 | n = 9 |
| Median (range) | 37 (4–102) | 57 (8–238) | 32 (6–36) |
| Patients with 28 days follow-up | n = 6 | n = 5 | n = 8 |
| RI recrudescence | n = 1 | n = 3 | n = 1 |
| Recrudescence on day | 23 | 21, 26, 27 | 20 |