Table 2.

Mean treatment differences between levocetirizine (or diphenhydramine) and placebo with 95% CI at 1, 2 or 3 h time point for the main trial tests, at day 1 and day 5.

	Levocetirizine 5 mg			Diphenhydramine 50 mg
Test	1 h	2 h	3 h	1 h	2 h	3 h
Day 1
CFF (Hz)	−0.15	−0.08	−0.81	−1.04	−1.14	−1.62
	(−1.15, 0.84)	(−1.07, 0.92)	(−1.80, 0.19)	(−2.03, −0.06)	(−2.13, −0.16)	(−2.61, −0.64)
CRT (ms)	−11.06	−7.33	0.22	8.50	10.00	15.22
	(−30.32, 8.21)	(−31.78, 17.11)	(−21.08, 21.53)	(−12.76, 29.76)	(−9.09, 29.09)	(−2.55, 32.99)
BS Distance displ. (cm)	3.26	2.42	6.19	7.35	7.99	16.35
Eyes closed	(−1.90, 8.41)	(−9.11, 13.94)	(−1.27, 13.64)	(−0.81, 15.50)	(−4.52, 20.50)	(5.61, 27.10)
LMT immediate recall	ND	0.61	ND	ND	−0.61	ND
		(−1.57, 2.80)			(−1.93, 0.71)
VAS Alertness score	−3.78	−4.47	−7.87	−4.88	−13.51	−17.09
	(−14.04, 6.48)	(−12.19, 3.25)	(−15.15, −0.60)	(−18.04, 8.27)	(−26.09, −0.92)	(−29.89, −4.28)
Day 5
CFF (Hz)	−0.18	0.16	0.15	0	−0.17	−0.63
	(−0.91, 0.54)	(−0.74, 1.06)	(−0.56, 0.86)	(−1.09, 1.09)	(−1.27, 0.94)	(−1.69, 0.43)
CRT (ms)	1.00	−8.22	−2.11	6.72	11.11	12.17
	(−14.97, 16.97)	(−30.45, 14.00)	(−20.15, 15.93)	(−4.93, 18.38)	(−6.06, 28.28)	(−2.09, 26.42)
BS Distance displ. (cm)	6.62	5.73	6.42	1.63	4.61	4.97
Eyes closed	(−2.20, 15.43)	(−3.96, 15.42)	(−2.08, 14.93)	(−6.08, 9.33)	(−2.35, 11.56)	(−3.58, 13.32)
LMT immediate recall	ND	−0.06	ND	ND	−0.56	ND
		(−1.38, 1.27)			(−0.94, 2.05)
VAS	0.77	7.19	5.47	0.31	−5.12	−4.20
Alertness score	(−4.17, 5.71)	(−1.12, 15.50)	(−2.49, 13.43)	(−8.82, 9.44)	(−13.61, 3.38)	(−12.55, 4.15)

ND:Not done.