Table 2.
Pharmacokinetic parameters of FU (mean ± s.d.).
| Dose (mg) | AUC (mg l−1 min−1) | CL (l min−1) | CL/kg (l min−1 kg−1) | Vss (l) | Vss/kg (l kg−1) | Vc § (l) | Final t1/2 (min) | Initial t1/2§ (min) | |
|---|---|---|---|---|---|---|---|---|---|
| All | 725±71 | 644±191 | 1.21±0.38 | 0.018±0.005 | 17.4±7.6 | 0.25±0.09 | 11.3±6.5 | 10.7±2.9 | 1.8±1.2 |
| Males (n = 21) | 756±51 | 680±209 | 1.24±0.36 | 0.017±0.005 | 17.5±8.4 | 0.24±0.11 | 12.3±7.3 | 11.1±3.1 | 2.2±1.2 |
| Females (n = 13) | 667±66* | 587±146 | 1.23±0.44 | 0.019±0.004 | 17.3±6.6 | 0.27±0.07 | 8.7±2.1 | 10.1±2.4 | 0.7±0.4 |
§
Parameter calculated only in the group of patients (n=22) with bi-exponential FU plasma concentration decay.
*
Significant difference between males and females.