Table 1.
Non-class III drugs reported to cause QT interval prolongation and/or torsade de pointes.
| Non-class III cardiovascular drugs | Non-cardiovascular drugs | |||
|---|---|---|---|---|
| Sodium channel blockers | Neuroleptics | Antidepressants | Antimicrobials | Anticancer drugs |
| Quinidine | Chlorpromazine | Amitriptyline | Erythromycin | Anthracycline |
| Disopyramide | Triflupromazine | Protriptyline | Co-trimoxazole | Aclarubicin |
| N-acetyl-procainamide | Promazine | Nortriptyline | Sulfamethoxazole | 5-fluorouracil |
| Lorcainide | Perphenazine | Butriptyline | Pentamidine | Acodazole |
| 3-Methoxy-O-desmethyl-encainide (MODE) | Fluphenazine | Desipramine | Amantidine | Adriamycin |
| Prochlorperazine | Imipramine | Grepafloxacin | Tamoxifen | |
| Ajmaline | Trifluoperazine | Lofepramine | Levofloxacin | S9788 |
| Triethylperazine | Clomipramine | Moxifloxacin | 502U83 | |
| Antianginals | Haloperidol | Doxepin | Sparfloxacin | Arsenic trioxide |
| Prenylamine | Trifluoperidol | Maprotiline | Gatifloxacin | Efavirenz |
| Fendiline | Droperidol | Dothiepin | Clarithromycin | |
| Lidoflazine | Penfluridol | Citalopram | Spiramycin | Miscellaneous |
| Bepridil | Fluspirilene | Zimeldine | Fluconazole | Vincamine |
| Aprindine | Risperidone | Fluoxetine | D0870 | Probucol |
| Terodiline | Ziprasidone | Antimoniates | Glibenclamide | |
| Perhexiline | Amisulpride | H1-Antihistamines | Epoprostenol | |
| Amiodarone | Chlorprothixene | Terfenadine | Serotonin (5-HT2)-antagonists | Chloral hydrate |
| Tedisamil | Thiothixene | Astemizole | Ketanserin | Amiloride |
| Mibefradil | Thioridazine | Diphenhydramine | Amperozide | Bromocriptine |
| Sertindole | Promethazine | Retanserin | Sevoflurane | |
| α1/β blockers | Pimozide | Hydroxyzine | Pipamperone | Cisapride |
| Sotalol | Zotepine | Tacrolimus | ||
| Oxprenolol | Quetiapine | Antimalarials | Serotonin (5-HT3)-antagonists | Levacetylmethadol |
| Nifenalol | Olanzapine | Halofantrine | Dolasetron | Lubelozole |
| Indoramin | Chloroquine | Zatosetron | Tiapride | |
| Melperone | Arteether | Tizanidine | ||
| Amosulalol | Rivastigmine | |||
| Cocaine | ||||
| Inotropic agents | Domperidone | |||
| Dobutamine | Bupivacaine | |||