Table 4.
Effect of rate-correction formula on mean change in QTc interval from baseline.
| Ziprasidone | Risperidone | Olanzapine | Quetiapine | Thioridazine | Haloperidol | |
|---|---|---|---|---|---|---|
| Increase in QT interval (ms) | 6.8 | −12.1 | −8.9 | −12.2 | 18.7 | 12.5 |
| Change in heart rate (beats min−1) | 4.6 | 9.5 | 6.5 | 11.2 | 5.7 | −2.9 |
| Change in QTc (ms) interval corrected by | ||||||
| Bazett (α = 0.50) | 20.3 | 11.6 | 6.8 | 14.5 | 35.6 | 4.7 |
| FDA-proposed (α = 0.37) | 16.5 | 4.9 | 2.3 | 6.9 | 30.8 | 6.8 |
| Baseline (α = 0.35) | 15.9 | 3.9 | 1.7 | 5.7 | 30.1 | 7.1 |
| Fridericia (α = 0.33) | 15.5 | 3.1 | 1.1 | 4.8 | 29.6 | 7.3 |