Table 5.
Effect of rate-correction formula on number of outliers with categorical change in QTc interval of >60 ms from baseline in the absence (and in the presence) of a metabolic inhibitor of the drug concerned.
| Ziprasidone | Risperidone | Olanzapine | Quetiapine | Thioridazine | Haloperidol | |
|---|---|---|---|---|---|---|
| Increase in QT interval (ms) | 6.8 (10) | −12.1 (1.1) | −8.9 (−1.8) | −12.2 (−15.8) | 18.7 (33.3) | 12.5 (22.5) |
| Change in heart rate (beats min−1) | 4.6 (3.6) | 9.5 (0.5) | 6.5 (3.0) | 11.2 (15.1) | 5.7 (−2.1) | −2.9 (−5.7) |
| Number of patients | ||||||
| Completing the study | 31 (31) | 25 (20) | 24 (24) | 27 (27) | 30 (30) | 27 (20) |
| With categorical increase in QTc (ms) interval corrected by | ||||||
| Bazett (α = 0.50) | 7 (3) | 2 (0) | 1 (0) | 3 (4) | 9 (6) | 1 (0) |
| Baseline (α = 0.35) | 2 (2) | 0 (0) | 0 (0) | 0 (0) | 5 (7) | 0 (0) |