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Metabolism of tamoxifen (1–10 µm, 1% dimethyl sulfoxide, n = 1) to Z-4-OH-tam in supersomes with expressed CYP2C9.1 (▪), CYP2C9.2 (▴) and CYP2C9.3 (•) proteins. The line represents that of best fit from linear regression with an estimate of in vitro intrinsic clearance provided by the slope.
